Author

Fang Huang

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Open access Oct 2026

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highly variable genes without considering exp...

Fang Huang, Da-Yu Hu, Ya-Qi Dai et al. · Advancement of science · 0 citations

Open access Sep 2026

Estrogen deprivation exacerbates Alzheimer’s disease pathology through neuronal CTSS signaling

Alzheimer’s disease (AD) exhibits a pronounced sex bias, with women facing disproportionately higher risk and more severe pathology. Postmenopausal estrogen decline is implicated in this vulnerability, yet the molecular mechanisms linking estrogen loss to AD pathogenesis remain incompletely understood. Here, we demonst...

Ren-Zhi Yang, Lin Shao, Fang Huang et al. · Journal of Neuroinflammation · 0 citations