TMEM97 links endoplasmic reticulum stress to hepatic stellate cell activation in experimental liver fibrosis: pharmacological attenuation by CT1812.
Liver fibrosis lacks broadly effective antifibrotic therapies, and activated hepatic stellate cells drive extracellular matrix deposition. We investigated whether transmembrane protein 97 (TMEM97), the σ-2 receptor, contributes to hepatic stellate cell (HSC) activation and whether the σ-2 receptor complex antagonist CT...