Integrative multi-omics reveals a prognostic and therapeutic landscape of synthetic lethality-associated signatures in lung adenocarcinoma
Summary Lung adenocarcinoma (LUAD) exhibits considerable heterogeneity and therapeutic resistance. Here, we integrated single-cell RNA sequencing, spatial transcriptomics, and machine learning to characterize synthetic lethality (SL)-associated transcriptional activity in LUAD. We quantified SL activity across malignan...