Fang-Xiong Cheng

SOCS1/Wnt/IL-1β axis negatively regulates macrophage extracellular traps and M1 polarization through the TNF pathway in crystalline kidney injury.

In the renal microenvironment of CaOx crystal deposition, IL-1β induces METs formation by activating the TNF signaling pathway and promotes M1 polarization, and SOCS1 and the TNF signaling pathway are identified as potential therapeutic targets for interrupting this positive feedback loop and mitigating sterile kidney...

Transient tubular membrane injury is converted into persistent fibrosis through a macrophage–fibroblast relay

RETRACTED ARTICLE: Long noncoding RNA UCA1 targets miR-582-5p and contributes to the progression and drug resistance of bladder cancer cells through ATG7-mediated autophagy inhibition

Evidence is provided for a novel UCA1 interaction regulatory network in bladder cancer, that is, UCA1-miR-582-5p-ATG7-autophagy axis, which provides a new insight into the treatment of bladder cancer.

AARS1‐Mediated H3K27 Lactylation Rewires Glycolysis to Sustain Aggressive and Recurrent Bladder Cancer

This work identifies alanyl tRNA synthetase 1 (AARS1) as a clinically relevant driver of aggressive and recurrent BC and defines an AARS1 associated metabolic and epigenetic program in BC and nominate AARS1 targeting strategies as a direction for further therapeutic development.