The cGAS-STING/MITA pathway in innate antiviral immunity and beyond
Upon binding double-stranded DNA (dsDNA), the cyclic GMP-AMP (cGAMP) synthase (cGAS) catalyzes the synthesis of 2′,3′-cGAMP, which subsequently binds to the endoplasmic reticulum (ER)-resident adaptor STING/MITA and triggers STING trafficking to the Golgi apparatus and recruits TANK-binding kinase 1 (TBK1) to induce ty...