Author

Fangzhu Zhao

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Open access Sep 2026

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells.

Tumor reliance on antioxidant defenses creates a vulnerability to ferroptosis, yet strategies to therapeutically disable these systems remain limited. Here, we identify targeted degradation of the selenium uptake receptor lipoprotein receptor-related protein 8 (LRP8) as an effective approach to decrease the abundance o...

Fang-Zhu Zhao, Alex Inague, Trenton M. Peters-Clarke et al. · Proceedings of the National... · 0 citations

Open access Aug 2026

Directed evolution of a stem-helix–targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

The isolation of a human monoclonal antibody from a SARS-CoV-2 convalescent donor that targets the conserved S2 stem helix region is reported, demonstrating the potential of in vitro affinity maturation to expand the neutralization breadth of stem-helix-targeting antibodies across divergent betacoronaviruses.

Panpan Zhou, M. Yuan, Yue-Xiu Zhang et al. · PLoS Pathogens · 0 citations