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Author

Fangyan Chen

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Open access Aug 2026

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

It is found that A. cavernosa retains the full eukaryotic ancestral mevalonate pathway for terpene precursor biosynthesis, providing additional evidence for the ancestral origin of metazoan terpenoid biosynthesis and further the understanding of early metazoan adaptive evolution.

Fangyan Chen, Bao Chen, Wen-Hui Zhang et al. · 0 citations
Jul 2026

Engineering a series of Scaffold-associated isoprenol utilization pathways to enhance terpene production spanning diverse chain lengths.

Terpenoids are valuable resources for pharmaceutical research, yet their natural supply remains constrained. While the artificial isoprenol utilization pathway (IUP) has emerged as a promising alternative for terpene precursor supply, its full potential is limited by suboptimal pathway flux and substrate tolerance. Her...

Lijun Liu, Xiaoyu Shi, Fangyan Chen et al. · 0 citations

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