Review
Aug 2026
From biology to therapy: advances in progranulin-related neurodegenerative diseases
A lysosome-centered framework for understanding PGRN-related neurodegenerative pathologies is presented, and TMEM106B is discussed as a critical genetic modifier within this lysosomal network, highlighting its role in shaping disease risk and phenotypic heterogeneity.
Sixian Hu, Kairui Qiu, Fangyuan Zhen et al.
· Molecular Neurodegeneration... · 0 citations