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Author

Fangzhu Zhao

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Open access Sep 2026

Targeted extracellular degradation of LRP8 promotes ferroptosis in cancer cells

Significance Many therapy-resistant cancers depend on the selenium-containing enzyme glutathione peroxidase 4 (GPX4) to suppress ferroptosis, an iron-dependent form of cell death driven by lipid peroxidation. Direct inhibition of GPX4 has proven challenging because of toxicity and limited drug-like properties of existi...

Fang-Zhu Zhao, Alex Inague, Trenton M. Peters-Clarke et al. · 0 citations
Open access Aug 2026

Directed evolution of a stem-helix–targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

The isolation of a human monoclonal antibody from a SARS-CoV-2 convalescent donor that targets the conserved S2 stem helix region is reported, demonstrating the potential of in vitro affinity maturation to expand the neutralization breadth of stem-helix-targeting antibodies across divergent betacoronaviruses.

Panpan Zhou, M. Yuan, Yue-Xiu Zhang et al. · 0 citations

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