Author

Farid M. Sroor

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Aug 2026

Novel [1,2,4]triazolo[1,5-a]pyrimidine derivatives as promising antioxidant and antimicrobial agents: Synthesis, antibiofilm, DFT calculations, molecular docking, ADMET analysis, and MD simulations.

The escalating threat of antimicrobial resistance necessitates the discovery of novel therapeutic scaffolds with distinct mechanisms of action. A novel series of [1,2,4]triazolo[1,5-a]pyrimidine derivatives (FNT01-12) featuring various aromatic substitutions at positions 5 and 7 was designed, synthesized, and evaluated...

Farid M. Sroor, Ahmed F. El-Sayed · Bioorganic chemistry (Print) · 0 citations

Jul 2026

Design, robust synthesis, and anti-liver cancer activity of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives: In vitro, gene expression, DNA damage, and DNA fragmentation.

A novel series of 2-hydrazono-5-acetyl-[1,3,4]thiadiazole and N'-ethylideneethanethiohydrazide derivatives tested as anticancer agents against a panel of cancer cell lines, and the mechanism of action of the most active compounds against liver cancer was explored through gene expression, DNA damage, and DNA fragmentati...

Ashraf A. Sediek, Eman Sabry, Huda F. Khalil et al. · Bioorganic chemistry (Print) · 0 citations