Review
Aug 2026
Armoring CAR-T Cells Against Exhaustion: Engineering Strategies for Glioblastoma.
Locoregional delivery consistently outperforms systemic administration, demonstrating that physical barriers are as critical as cellular engineering in GBM, and antigen heterogeneity, metabolic limitations, and the need for combinatorial targeting remain the principal unresolved challenges.
Ali Anvarian, Fatemeh S. M. Nazari, Ali Karimi Jashni
· Journal of immunotherapy · 0 citations