Diagnostic utility and tissue localization of HPV16 and HPV18 E7 immunohistochemistry in cervical lesion progression: a comparative study with PCR
Background Persistent infection with high-risk human papillomavirus (HPV), particularly HPV16 and HPV18, contributes to cervical carcinogenesis through sustained expression of the viral E7 oncoprotein. Although HPV DNA polymerase chain reaction (PCR) is widely used for viral detection, it does not directly reflect biol...