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Author

Fatma M Elmenier

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Review Open access Jul 2026

FLT3 inhibitors in AML: from classic scaffolds to next-generation approaches

This review analyzes how hinge contacts, back-pocket occupancy, and warhead placement govern activity across wild-type and mutant FLT3, and links binding mode, covalent engagement, and second-target selection to recurrent resistance biology to guide more resilient FLT3-targeted therapies for high-risk AML.

Fatma M Elmenier, Eman M. E. Dokla, Nermin Samir et al. · 0 citations

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