A REVIEW ON STRUCTURAL OPTIMIZATION OF BETALACTAM ANTIBIOTICS AND DEVELOPMENT OF ?ETALACTAMASE INHIBITORS AGAINST ESBL-MEDIATED RESISTANCE
Extended-Spectrum ?-Lactamase (ESBL)-mediated antimicrobial resistance has become a major challenge in treating Gram-negative bacterial infections by reducing the efficacy of ?-lactam antibiotics. This review evaluates the structural modification strategies of ?-lactam antibiotics and the development of next-generation...