Human genetics has substantially advanced our understanding of the Rho GTPase signaling network in brain development and established its dysregulation as an important mechanism underlying neurodevelopmental disorders (NDDs). Through the spatiotemporal control of actin cytoskeleton dynamics, canonical and atypical Rho G...
A. Falace, Mohammad Sadegh Shams Nosrati, Alireza Dostmohammadi et al.· Neurobiology of Disease· 0 citations
Advances reframe kinesinopathies as mechanistically stratified disorders of neuronal transport as well as translational implications, including variant-resolved diagnosis and precision strategies to restore transport, dampen pathological hyperactivity, or stabilize the microtubule track.
Mohammad Sadegh Shams Nosrati, Morteza Doustmohammadi, Alireza Dostmohammadi et al.· Current Issues in Molecular...· 0 citations
It is demonstrated that early-onset MORC2-associated disorders segregate into two principal neurological phenotypes: a predominantly neuromuscular form and a central nervous system-predominant form.
A. Murtazina, Eugenii Tatarsky, I. Viakhireva et al.· Journal of Medical Genetics· 0 citations
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