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Open access Jul 2026

Nanoporous gold electrode-assisted CRISPR/Cas12a electrochemical detection of synthetic methylated DNA models for breast cancer liquid-biopsy development

Circulating tumor DNA (ctDNA) methylation is a promising liquid-biopsy signal for early breast cancer, but low target abundance, fragmented cell-free DNA (cfDNA), and matrix fouling remain major barriers to electrochemical implementation. Here, a nanoporous gold (NPG) electrode-assisted CRISPR/Cas12a electrochemical as...

Xiaohui Wang, Fujiang Zhang, Huaijiang Yu et al. · 0 citations

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