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Open access Sep 2026

Targeting p38α promotes Parkin-mediated mitophagy to attenuate severe acute pancreatitis via suppressing the mtDNA/cGAS-STING signaling pathway

This study illuminates a novel role of the p38α/Parkin/mtDNA/cGAS-STING signaling axis in the pathogenesis of SAP, and highlights targeting the p38α-mediated Parkin S131 phosphorylation switch as a promising therapeutic strategy for clinical intervention against SAP.

Xiao-Zhou Xie, Jie Li, Hao-Yu Zhang et al. · 0 citations

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