Open access
Aug 2026
A dual A-to-Y and G-to-Y base editor and a four-base concurrent hypermutator in mammalian cells
A compact dual base editor “A&GBE” is engineer by fusing a deaminase and glycosylase with nickase Cas9 to enable concurrent adenine and cytosine editing and develops quadruple base mutating modules (QBMM) that enables simultaneous mutation of all four types of nucleotide bases.
Na Zhao, J. S. Olajide, Zhihong Guan et al.
· Nature Communications · 0 citations