A Modular Endogenous-Responsive DNA Nanosponge for Cancer-Selective RNA Demethylase Imaging and Concurrent Photodynamic Therapy.
Both in vitro and in vivo studies validate the feasibility of this robust and versatile nanoplatform that merges targeted delivery and endogenous activation for precise cancer imaging and therapy, with the potential for adaptation to diverse sensing and therapeutic payloads through modular reprogramming.