Development of Sex-Specific Physiologically Based Toxicokinetic (PBTK) Models for GenX in Mice and Their Application to Human Health Risk Assessment.
GenX (hexafluoropropylene oxide dimer acid, HFPO-DA), a widely used alternative to perfluorooctanoic acid (PFOA), has raised significant concerns due to its multi-system toxicity and potential human health risks. Accumulating evidence indicates that both the toxicokinetics and toxicity of GenX exhibit marked sex-specif...