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Fei-Ran Wang

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Open access Sep 2026

PLXDC2 siRNA‐Mediated Intervention Attenuates Microglial Senescence Through cGAS‐STING Signaling

ABSTRACT Parkinson's disease (PD) is driven by neurodegeneration, iron accumulation, and microglial senescence, yet effective therapy is hindered by the blood–brain barrier (BBB). By constructing the largest‐to‐date single‐cell atlas of the human substantia nigra, we identified a marked upregulation of PLXDC2 in PD mic...

He-Yue Lu, Zi-Tian Zheng, Fei-Ran Wang et al. · 0 citations

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