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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Fei Xiong

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Sep 2026

Discovery of Pyranochromone Derivatives as TLR4-MD2 Inhibitors for Alleviating Osteoarthritis

Calomembranone G, isolated from Calophyllum membranaceum, displays in vivo anti-inflammatory activity in models of arthritis and acute lung injury. Using natural product calomembranone G as a hit compound and leveraging a strategy of structural simplification, a total of 66 pyranochromone derivatives were synthesized...

Ming-Shi Pan, Rong Wang, Jian-Qiang Qian et al. · 0 citations

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