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Author

Fei Zhao

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Open access Jul 2026

Protein-confined imidazolium intermediates enable diverse biocatalytic C–C and C–N bond formations

Developing enzymatic strategies to selectively construct C–C and C–heteroatom bonds is a major objective in modern biocatalysis. Here we combine genetic code reprogramming and laboratory evolution to establish a family of allylic transferase enzymes that can achieve a remarkable breadth of chemistry, enabling the gener...

Zachary Birch-Price, A. E. Hutton, Fei Zhao et al. · 1 citation

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