Author

F. Vilicich

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Open access Oct 2026

Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells.

Autophagy dysfunction and senescence are established drivers of aging, but their potential interaction remains poorly understood. Here we show that age-related decline of chaperone-mediated autophagy (CMA), a pathway for selective lysosomal protein degradation, changes senescent cell properties and impairs their immune...

Rebecca Sereda, Kristen Lindenau, Antonio Díaz et al. · Nature Aging · 1 citation

Open access Jun 2026

Inferring dynamic information from protein structures by Gaussian integrals and deep learning

Abstract Motivation Protein dynamics are central to function, but experiments and molecular dynamics (MD) simulations remain costly, low-throughput, and difficult to compare across protocols. Scalable structure-based methods are needed to infer dynamics from static protein structures. Results We present a deep learning...

F. Vilicich, Nicolás Bottino, Zhaoqian Su et al. · Bioinform. · 0 citations