Parkinson’s disease genetic risk converges on Lewy body pathology-associated microglial states
Parkinson's disease (PD) and related -synucleinopathies are defined by the spread of Lewy body (LB) pathology across vulnerable brain regions, yet how substantia nigra (SN) myeloid cells respond remains unresolved. Using SOX10-based oligodendrocyte depletion and CD11b-based myeloid enrichment, we profiled 169,799 brain...