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Author

Fen-Ge Li

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Open access Oct 2026

CXCR5 regulates CD8+/GZMB+ T cell infiltration and apoptotic signaling in breast cancer

Summary Emerging evidence associates CXCR5 expression with immunotherapy outcomes; however, the intrinsic role of tumor-derived CXCR5 in modulating chemo-immunotherapy sensitivity in triple-negative breast cancer (TNBC) remains uncharacterized. This study was conducted using murine 4T1 and human MDA-MB-231 TNBC models....

W. Feng, Jin Yan, Xue Gong et al. · 0 citations
Clinical trial Open access Aug 2026

T cell receptor repertoire dynamics and newly identified functional regulators of autologous tumor-infiltrating lymphocyte therapy in advanced solid tumors

The efficacy of TIL therapy in diverse solid tumors among Asian patients is demonstrated, dynamic TCR clonal remodeling in responders is revealed, and ASS1 and CEP20 knockout as strategies to potentiate antitumor activity are identified.

Fen-Ge Li, Ji-Long Yang, Gregory A. Lizee et al. · 0 citations

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