Fen-Juan Chen

AI and computational methods for reconstructing cell-state-specific gene regulatory networks from single-cell transcriptome and chromatin accessibility data in cancer: methods, applications, and perspectives

Tumor heterogeneity is shaped by genetic, epigenetic, microenvironmental, and stochastic factors, among which cell-state-specific regulatory programs are a major determinant. Gene regulatory networks provide a systems-level model linking transcription factors, cis-regulatory elements, and target genes. Paired single-ce...