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Open access Sep 2026

Sequence variations govern the hierarchical self-assembly and structural polymorphism of PSM-α functional amyloids.

Biofilm-associated functional amyloids reinforce extracellular matrices and enhance microbial resistance to environmental and antimicrobial stresses. In Staphylococcus aureus, phenol-soluble modulins (PSMs), particularly the PSM-α family, regulate biofilm maturation and pathogenicity through sequence-dependent self-ass...

Feng-Juan Huang, Yi-Ran Wang, Hao Sun et al. · 0 citations
Open access Aug 2026

Multi-pathway aggregation drives concentration-dependent amyloid polymorphism and time-dependent morphological evolution

Amyloid aggregation into polymorphic fibrils is central to many neurodegenerative and systemic diseases, yet the physical origins of fibril polymorphism and time-dependent morphological evolution remain unclear. Because mature fibril morphologies are separated by high energy barriers, direct interconversion is unlikely...

Kamal Bhandari, Wuzhou Xiong, Tianyi Hou et al. · 0 citations

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