Author

Feng-Dong Zhao

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Open access Oct 2026

Three-dimensional bioglass-nanoclay scaffold with localized controlled release of 4-octyl itaconate promotes bone regeneration in osteoporotic bone defects.

Osteoporotic bone defect repair is a complex physiological process occurring under pathological conditions, which primarily involves the inhibition of bone resorption and the promotion of bone formation. In recent years, composite scaffolds for localized drug delivery have been developed to enhance the healing of osteo...

Tian-Ming Yu, Xiang-Xi Kong, Wei Wang et al. · Biomedical Materials · 0 citations

Open access Oct 2026

Polyol Pathway Inhibition by Epalrestat Attenuates Pathological Bone Loss through Redox Homeostasis and Sorbitol-Linked Calcium Signaling.

The contribution of polyol metabolism to pathological bone remodeling remains incompletely understood. Here, we examined its role in osteoclastogenesis and evaluated the skeletal effects of epalrestat, a clinically approved aldose reductase inhibitor. Exploratory single-cell analysis of two human femoral-head specimens...

Cheng-Lun Yao, Zi-Min Cai, Hai-Xin Song et al. · Pharmacological Research · 0 citations