Allosteric Switching-Triggered Electrocatalyst Recruitment Enables Indicator-Free, Milliampere-Level Hydrogen Evolution Readout for MicroRNA-21 Detection
Electrochemical nucleic acid biosensors typically rely on redox labels or exogenous mediators to generate analytical signals, which can complicate assay design and constrain signal magnitude. Herein, we report an enzyme-free and indicator-free electrochemical biosensor for microRNA-21 based on allosteric switching-tr...