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Open access Oct 2026

MAMDC2 drives microglia-mediated neuroinflammation via CAND1-dependent IκBα ubiquitination and is targetable by Artemvulactone E.

Sustained microglial activation is a common feature of many neurological disorders, yet the upstream molecular amplifiers that sustain this process remain poorly defined. Our earlier work identified MAM domain-containing 2 (MAMDC2) as an immune regulator enriched in microglia with an established role in antiviral immun...

Tao Liu, Feng Gao, Yi-Liang Wang et al. · 0 citations
Review Oct 2026

Decoding the IL-12 Cytokine Family in Sjögren's Disease: Pathogenic Networks and Translational Implications.

BACKGROUND Sjögren's disease (SjD) is a systemic autoimmune disorder characterized by exocrine-gland dysfunction and heterogeneous extraglandular manifestations. The IL-12 cytokine family, comprising IL-12, IL-23, IL-27, and IL-35, may contribute to SjD through interconnected immune and JAK-STAT signaling pathways. O...

Man-Yu Han, Jia-Qi Yang, Feng Gao et al. · 0 citations

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