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Author

Feng-Jiao Huo

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Open access Sep 2026

CBX4 stabilizes NEUROD1 through SUMO-ubiquitin crosstalk to delay β-cell senescence

Aging-associated β-cell senescence is a key driver of type 2 diabetes mellitus (T2DM). However, its associated molecular mechanisms remain poorly explored. This study identifies Chromobox 4 (CBX4), a Polycomb group protein with SUMO E3 ligase activity, as an essential regulator of β-cell aging and function. The results...

Lin-Min Su, Yan Liu, Qian-Xing Hu et al. · 0 citations

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