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Author

Feng-Lin Li

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Open access Oct 2026

H4K12 Lactylation Impairs Dopaminergic Neuron Energy Metabolism via the HIF‐1α/NDUFS1 Pathway in Parkinson's Disease

ABSTRACT Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic (DA) neurons in the substantia nigra, with mitochondrial dysfunction central to its pathology. Recent studies have linked lactate—accumulating in PD due to mitochondrial dysfunction—to disease mechani...

Ying-Yao Liu, Xi Li, Wen-Xuan He et al. · 0 citations
Open access Jul 2026

Serum total cholesterol and low-density lipoprotein cholesterol are associated with Parkinson’s disease in East Asian populations: a bidirectional Mendelian randomization study with complementary animal observation

Background Dysregulation of lipid metabolism has been implicated in Parkinson’s disease (PD), yet causal relationships remain unclear due to confounding factors inherent in observational studies. Most Mendelian randomization studies on lipid-PD relationships have been conducted in European populations, leaving the caus...

Yanzi Bao, huaxin Huang, Wei Feng et al. · 0 citations

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