BACKGROUND
Cardiometabolic risk associated with obesity is increasingly recognized to be strongly influenced by the anatomical distribution and ectopic deposition of adipose tissue, yet the genetic mechanisms linking adipose depots to cardiometabolic diseases remain incompletely understood.
METHODS
Using large-scale...
Qian Wu, Fan Yang, Qi An et al.· Journal of the American Hear...· 0 citations
Diffusion tensor image analysis along the perivascular space (DTI‐ALPS) index is associated with neurodegenerative diseases (NDDs), but its shared genetic basis with NDDs remains unclear.
Hong Zhou, Jia-Lin Deng, Qian Wu et al.· Alzheimer's & Dementia· 0 citations
Two distinct ACEs-related pathways influencing adolescent behavior through neurostructural and functional mediators, moderated by genetic risk are delineated, advances the understanding of ACEs mechanisms and highlights targets for early intervention.
Huaigui Liu, Jie Tang, Zhen Zhao et al.· Developmental Cognitive Neur...· 0 citations
This study provides a multi-scale characterization of the shared genetic architecture between MD and intrinsic brain functional connectome organization, revealing that shared genetic signals between MD and brain functional systems are distributed across multiple functional levels and converge at the molecular level.
Qi An, Ying Zhai, Wen-Jie Cai et al.· Progress in Neuro-psychophar...· 0 citations
The findings reveal partial genetic overlap between altered brain aging and diverse psychiatric disorders, providing an integrative cross-modality perspective on the shared genetic influences and related biological pathways linking brain aging and psychiatric vulnerability.
Qi-Yu Zhao, Qi An, Wen-Jie Cai et al.· Molecular Psychiatry· 2 citations
The shared genetic architecture between SCZ and subcortical brain susceptibility phenotypes is dissected by integrating large-scale genome-wide association study data with quantitative susceptibility mapping (QSM) phenotypes across 16 subcortical regions, highlighting pathways that may offer novel therapeutic strategie...
Yingying Xie, Jiaojiao Du, Yao Zhao et al.· Schizophrenia· 0 citations
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