Feng-Liu Lu

Metabolic Engineering of Yarrowia lipolytica for De Novo Biosynthesis of Umbelliferone

Umbelliferone, a key precursor for the biosynthesis of high-value furanocoumarin derivatives, is produced via the shikimate pathway. The oleaginous yeast Yarrowia lipolytica possesses an inherently robust shikimate pathway; however, de novo biosynthesis of umbelliferone in this microbial chassis has not been realized t...