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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Feng-Tao Liu

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Open access Aug 2026

Cholesterol enhances lysosome-autophagosome fusion for better α-synuclein clearance in GBA L444P-mutated Parkinson disease.

It is reported, in a large cohort, that GBA-mutated PD patients exhibit lower serum cholesterol levels and cholesterol supplementation was found to enhance the autophagic flux and mitigate α-synuclein accumulation in vitro, whereas AAV-Srebp2 delivery increased α-synuclein clearance in GbaL444P/+ mice.

Mingjia Chen, Feng-Tao Liu, Yu-Jie Yang et al. · 0 citations

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