Author

Feng-Tao Zhou

3 papers indexed here

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Sep 2026

Design, synthesis and biological evaluation of a series of new, potent FLT3 PROTAC degraders with rigid linkers.

Fms-like tyrosine kinase 3 (FLT3), a member of the type III receptor tyrosine kinase family, is identified as a promising drug target for treatment of acute myeloid leukemia (AML). Here, we designed and synthesized a series of new FLT3 PROTAC degraders by incorporating rigid linkers between gilteritinib and CRBN ligand...

Li-Cheng Zhou, Ying-Long Chen, Jia-He Li et al. · Bioorganic & Medicinal Chemi... · 0 citations

Open access Sep 2026

Single-Atom Modification Enables Reversal of Degradation Selectivity between NSD2 and GSPT1

These findings demonstrate that minimal structural alteration permits precision control over degrader target selectivity, while furnishing selective chemical probes for NSD2 and GSPT1.

Wei-Zhong Shen, Yi-Han Liu, Lian-Chao Liu et al. · bioRxiv · 0 citations

Open access Sep 2026

Molecular Editing in Protein Degradation: From a Dual NSD2/GSPT1 Degrader to an NSD2-Selective PROTAC and a GSPT1-Selective Molecular Glue

Molecular editing, rooted in synthetic chemistry, has emerged as a powerful tool for structure optimization in medicinal chemistry but remains underutilized in targeted protein degradation. Here, we demonstrate the utility of molecular editing by repurposing the NSD2 degrader LLC0424 with GSPT1 neosubstrate engagement...

Wei-Zhong Shen, Yi-Han Liu, Lian-Chao Liu et al. · bioRxiv · 0 citations