Open access
Jul 2026
Lipophilic Ligand Efficiency-Monitored Discovery of Potent, Achiral, and Bioavailable Apo-IDO1 Inhibitors.
This work describes the IDO1 inhibitor discovery and optimization effort, in which the lipophilic ligand efficiency index was used to track and guide drug-likeness, minimize entropic penalty, and deliver novel, potent, selective, and orally bioavailable apo-IDO1 inhibitors.
W. Kazmierski, Nagaraju Miriyala, M. A. De La Rosa et al.
· ACS Medicinal Chemistry Lett... · 0 citations