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Open access Sep 2026

Machine learning and multi-omics clustering to map cellular rewiring and immune evasion in ccRCC

Immune checkpoint blockade (ICB) efficacy in clear cell renal cell carcinoma (ccRCC) is limited by tumor microenvironment (TME) heterogeneity. Because traditional bulk-derived models lack spatial resolution, we developed an integrated framework connecting macroscopic survival risks to microscopic TME structures. We app...

Zhe Wang, Ying-Jian Wang, Jia-Yi Zhang et al. · 0 citations

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