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Author

Feng-Xi Li

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Aug 2026

Reprogramming ω -Transaminase for Enantioselective Assembly of Axially Chiral Spiro[3.3]heptane Building Blocks

Axially chiral amines embedded in rigid spirocyclic frameworks are valuable motifs in medicinal chemistry, yet their synthesis by direct asymmetric amination of sterically congested ketones remains highly challenging. Here, we report an engineered ω-transaminase variant for the direct asymmetric amination of 2,6-disu...

Zi-Yi Lin, Meijiao Gao, Qikai Sun et al. · 0 citations

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