Role of ALDH2 in myocardial ischemia-reperfusion injury: using ALDH2 as a potential therapeutic target
The role of mitochondrial aldehyde dehydrogenase 2 (ALDH2) is summarized as both an endogenous cardioprotective enzyme and a potential therapeutic target in myocardial I/R injury, and clinical translation will require genotype-informed patient stratification, optimization of ALDH2-targeted agonists, and careful timing...