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Open access Sep 2026

Knockdown of CHI3L1 Attenuates Venous Intimal Hyperplasia by Modulating Vascular Inflammation and Oxidative Stress via the JNK/ERK Pathway

Background: Venous intimal hyperplasia (VIH) is the key pathological basis for early failure of arteriovenous fistula (AVF) and for stenosis of hemodialysis access. Chitinase-3-like protein 1 (CHI3L1) is highly expressed during cardiovascular remodeling and inflammation, but its role and underlying mechanisms in AVF-re...

Si-Shi Yan, Ji Xu, Feng Yao et al. · 0 citations

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