Open access
Sep 2026
Glycine betaine-mediated transcriptional stimulation links its catabolism and vitamin B12 biosynthesis in Rhizobiaceae
Glycine betaine (GB) is a trimethylated ammonium compound widely used as a compatible solute, and serves as a carbon, nitrogen, and methyl group source in many members of the Rhizobiaceae. GB is critical for high-level vitamin B₁₂ production, a cofactor synthesized exclusively by microorganisms. Vitamin B12 formation r...
C. Rauch, Tamara Hoffmann, Marcela Wagner et al.
· bioRxiv · 0 citations