Author

Floralba Gjergjova

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Jul 2026

Regulatory T cell immunosuppressive function requires chaperone-mediated autophagy.

Regulatory T cells (Tregs) are essential for maintaining immune tolerance. We recently identified chaperone-mediated autophagy (CMA), a selective lysosomal degradation pathway, as a critical regulator of Treg function. Treg activation induces CMA, but this response is markedly diminished with aging. Mice lacking CMA sp...

Ranee Harrison, Floralba Gjergjova, Susmita Kaushik et al. · Autophagy · 1 citation