Author

Florence Dô

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Open access Oct 2026

Immune-Complex-Based In Vitro Deubiquitination Assay

Deubiquitinases (DUBs) are attractive therapeutic targets within the ubiquitin-proteasome system, in part because four of the five DUB subfamilies are cysteine proteases amenable to the development of potent, selective inhibitors, as recently demonstrated for USP7. Identifying DUBs that deubiquitylate and stabilize spe...

Florence Dô, Sylvain Meloche, M. Servant · Bio-protocol · 0 citations

Open access Sep 2026

The orphan receptor IL-17RD is a negative regulator of RIG-I-like receptor-dependent antiviral innate immunity and restrains SARS-CoV-2-induced lung inflammation

Detection of viral RNA by the RIG-I-like receptors (RLRs) RIG-I and MDA5 triggers assembly of a MAVS-dependent signalosome that activates the TBK1-IRF3 and IKKβ-NF-κB axes together with the JNK and p38 MAPK modules, driving type I and type III interferon (IFN) and inflammatory cytokine production. Because unrestrained...

Firas El-Mortada, J. Roy, Charlotte Girondel et al. · bioRxiv · 0 citations