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Author

Florencia Salinas

1 paper indexed here

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Open access Sep 2026

LRSAM1, an E3 ubiquitin ligase, modulates TDP-43 proteostasis in amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the cytoplasmic mislocalization, aberrant phosphorylation and pathological aggregation of TDP-43, a nuclear RNA-binding protein essential for RNA metabolism. Despite its central involvement in ALS pathogenesis, the molecular mechanisms...

Takayuki Shirakawa, Satsuki Mikuriya, Yuki Inoue et al. · 0 citations

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