CDState Resolves Malignant Cell Heterogeneity from Bulk Tumor RNA-Sequencing Data.
CDState, an unsupervised deconvolution method based on nonnegative matrix factorization with a sum-to-one constraint and a cosine-similarity-based optimization, which infers malignant cell states using bulk RNA-seq data, is demonstrated to be utility for characterization of malignant cell states from bulk RNA-seq data.