Open access
Jul 2026
Repurposing Triamterene as Chloride Intracellular Channel 1 Inhibitor via Ligand-Based Approach: A Novel Adjuvant Treatment for Glioblastoma.
Triamterene emerges as a repurposed anti-glioblastoma agent with higher potency and tumor selectivity than metformin, together with its well-known favorable pharmacokinetic profile, which makes TMT a promising candidate for clinical translation in glioblastoma patients.
Federica Barbieri, F. Cianci, B. Tremonti et al.
· Molecular Therapy · 0 citations