Author

François Paquet-Durand

Institute for Ophthalmic Research

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Open access Aug 2026

Evidence for a rod-to-cone lactate shuttle in the mammalian retina

In his seminal 1920s studies, Otto Warburg found the retina to generate large amounts of lactate. However, it was unclear what retinal cells produced lactate and whether it was a metabolic waste product or used further. Here, we show that lactate produced by rod photoreceptors fuels the energy-intensive function and vi...

Lan Wang, Wadood Haq, Lucia Peiroten et al. · bioRxiv · 0 citations

Open access Sep 2026

PGC-1α and PPARs cooperatively mediate photoreceptor neuroprotection in rd1 mouse inherited retinal degeneration

The data support the concept of a PARP–sirtuin-1–PGC-1α–PPAR–PARP feedback control that connects defective energy metabolism to photoreceptor degeneration and highlights PPAR-signaling as a promising target for future therapeutic interventions.

Lan Wang, Jie Yan, J. Sancho-Pellúz et al. · Cell Death and Disease · 1 citation