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Author

Frank Speleman

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Review Open access Aug 2026

A functional landscape for chromosome 17q in neuroblastoma: balancing replication stress and genomic stability.

Improved understanding of the mechanisms by which 17q copy number-driven genes regulate replication stress responses and DNA damage repair may expose fundamental vulnerabilities in aggressive neuroblastoma and guide the development of novel targeted therapeutic strategies.

E. Hilgert, L. Depestel, N. Van Roy et al. · 0 citations
Jul 2026

SOX11 stimulates γδ T-cell differentiation and synergizes with LMO2 and MYCN to drive γδ-like T-cell acute lymphoblastic leukemia

Functional validation using genetic and transplantation-based mouse models demonstrated that SOX11 cooperates with MYCN to accelerate T-ALL onset and establish a cooperative SOX11–MYCN oncogenic axis driving γδ-like T-ALL.

André Almeida, Igor Fijalkowski, K. Christensen et al. · 0 citations

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